About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5490547
Allelic
Composition
Siglecetm1Arte/Siglecetm1Arte
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Siglecetm1Arte mutation (0 available); any Siglece mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• during LPS-induced acute lung airway inflammation, mice exhibit increased neutrophil and macrophage recruitment compared with wild-type mice
• mice exhibit increased neutrophil recruitment in response to intranasal zymosan compared with wild-type mice
• however, blockage of CD11B reverses increased recruitment in LPS-treated mice
• however, neutrophil recruitment is normal in thioglycollate-induced peritonitis and acute inflammation in an air pouch model induced by TNFa or Staphylococcus aureus
• during LPS-induced acute lung airway inflammation, mice exhibit increased neutrophil and macrophage recruitment compared with wild-type mice

hematopoietic system
• during LPS-induced acute lung airway inflammation, mice exhibit increased neutrophil and macrophage recruitment compared with wild-type mice
• mice exhibit increased neutrophil recruitment in response to intranasal zymosan compared with wild-type mice
• however, blockage of CD11B reverses increased recruitment in LPS-treated mice
• however, neutrophil recruitment is normal in thioglycollate-induced peritonitis and acute inflammation in an air pouch model induced by TNFa or Staphylococcus aureus
• during LPS-induced acute lung airway inflammation, mice exhibit increased neutrophil and macrophage recruitment compared with wild-type mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
04/30/2024
MGI 6.23
The Jackson Laboratory