Siglece^tm1Arte
Targeted Allele Detail

Summary

• Symbol: Siglece^tm1Arte
• Name: sialic acid binding Ig-like lectin E; targeted mutation 1, TaconicArtemis
• MGI ID: MGI:5490543
• Synonyms: siglec-E R126D
• Gene: Siglece Location: Chr7:43300494-43309585 bp, - strand Genetic Position: Chr7, 28.25 cM, cytoband B2
• Alliance: Siglece^tm1Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:195429
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 1 was replaced with one in which nucleotide substitutions result in the amino acid substitution of aspartic acid for arginine at position 126 (R126D). This mutation destroys the sialic acid binding site. An FRT-flanked neomyocin resistance cassette with a 5'loxP site was inserted downstream of exon 3. An additional loxP site was inserted downstream of exon 6. (J:195429)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Siglece Mutation: 31 strains or lines available

References

• Original: J:195429 McMillan SJ, et al., Siglec-E is a negative regulator of acute pulmonary neutrophil inflammation and suppresses CD11b beta2-integrin-dependent signaling. Blood. 2013 Mar 14;121(11):2084-94
• All: 2 reference(s)