Phenotypes Associated with This Genotype

Genotype
MGI:5490465

• Allelic Composition: Pdgfra^{tm1.1(cre/Esr1*)Nshk}/Pdgfra⁺; Runx1^tm1Medv/Runx1^tm1Medv
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:193389 )

• rescued embryos (tamoxifen treatment at E7.5) do not survive beyond E12.5

hematopoietic system

anemia ( J:193389 )

• rescued embryos (tamoxifen treatment at E7.5) are modestly anemic

abnormal hematopoietic cell number ( J:193389 )

• with tamoxifen treatment at E7.5, Runx1 expression is restored in the Pdgfra+ve mesoderm and this partially restores CD45+ve and Lin-Kit-Sca1+ve (KSL) hematopoietic cells (HPCs) in the fetal liver at E12.5; these populations are absent without tamoxifen treatment

• with tamoxifen treatment at E7.5, partial recovery of colony forming units (CFUs) from liver cells grown on methycellulose is observed, but without tamoxifen, fetal liver cells fail to generate colonies

integument

pallor ( J:193389 )

• rescued embryos (tamoxifen treatment at E7.5) are pale