Phenotypes for Fkbp1a Nkx2-5 MGI:5490242 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Fkbp1a^tm1.1Shou/Fkbp1a^tm1Zuk Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fkbp1a^tm1.1Shou mutation (0 available); any Fkbp1a mutation (14 available)
Fkbp1a^tm1Zuk mutation (0 available); any Fkbp1a mutation (14 available)
Nkx2-5^tm1(cre)Rjs mutation (1 available); any Nkx2-5 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:195489 )

• death occurs between E14.5 and birth

cardiovascular system

abnormal heart ventricle morphology ( J:195489 )

• mutants phenocopy Fkbp1a^tm1Zuk mice, showing hypertrabeculation, noncompaction, and ventral septal defects (VSDs) with complete penetrance

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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