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Phenotypes Associated with This Genotype
Genotype
MGI:5488659
Allelic
Composition		 Panx1tm1Vshe/Panx1tm1Vshe
Tg(Thy1-cre)1Vln/0
Genetic
Background		 B6.Cg-Panx1tm1Vshe Tg(Thy1-cre)1Vln
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Panx1tm1Vshe mutation (1 available); any Panx1 mutation (41 available)
Tg(Thy1-cre)1Vln mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased neuron apoptosis ( J:196355 )
• following ischemia/reperfusion injury
increased retina ganglion cell number ( J:196355 )
• following ischemia/reperfusion injury

homeostasis/metabolism
abnormal response to injury ( J:196355 )
• following ischemia/reperfusion injury, retina exhibit reduced retinal ganglion cell (RGC) loss and increased RGC and neuronal survival with less apoptosis compared with wild-type mice

vision/eye
increased retina ganglion cell number ( J:196355 )
• following ischemia/reperfusion injury

cellular
decreased neuron apoptosis ( J:196355 )
• following ischemia/reperfusion injury

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory