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Phenotypes Associated with This Genotype
Genotype
MGI:5487655
Allelic
Composition
Abhd12tm1Crv/Abhd12tm1Crv
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abhd12tm1Crv mutation (0 available); any Abhd12 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Age-dependent increase in microglial activation in Abhd12tm1Crv/Abhd12tm1Crv brain

behavior/neurological
• at 17 to 18 months
• blunted at 11 to 12 months
• mild at 17 to 18 months in the accelerating rotarod and hanging wire test
• however, young mice exhibit normal coordination
• modest in young, but not old, mice

hearing/vestibular/ear
• at 9 to 10 months, mice exhibit delayed absolute latencies of waves IV, V and VII and interpeak latencies of waves I to IV compared with wild-type mice
• however, brainstem auditory evoked potential remains intact

homeostasis/metabolism
• elevated lysophosphatidylserine lipids in the brain at 2 to 6 months
• mice exhibit reduced brain lysophosphatidylserine lipase compared with wild-type mice

nervous system
• at 12 months in the cerebellum
• at 18 months

muscle
• indicated by a decreased latency to fall at 17 to 18 months in the hanging wire test

vision/eye
N
• mice exhibit normal ocular structure and function

immune system
• at 12 months in the cerebellum
• at 18 months

hematopoietic system
• at 12 months in the cerebellum
• at 18 months


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory