Mouse Genome Informatics
hm
    Abhd12tm1Crv/Abhd12tm1Crv
involves: C57BL/6
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype

Age-dependent increase in microglial activation in Abhd12tm1Crv/Abhd12tm1Crv brain

behavior/neurological
• at 17 to 18 months
• blunted at 11 to 12 months
• mild at 17 to 18 months in the accelerating rotarod and hanging wire test
• however, young mice exhibit normal coordination
• modest in young, but not old, mice

hearing/vestibular/ear
• at 9 to 10 months, mice exhibit delayed absolute latencies of waves IV, V and VII and interpeak latencies of waves I to IV compared with wild-type mice
• however, brainstem auditory evoked potential remains intact

homeostasis/metabolism
• elevated lysophosphatidylserine lipids in the brain at 2 to 6 months
• mice exhibit reduced brain lysophosphatidylserine lipase compared with wild-type mice

nervous system
• at 12 months in the cerebellum
• at 18 months

muscle
• indicated by a decreased latency to fall at 17 to 18 months in the hanging wire test

vision/eye
N
• mice exhibit normal ocular structure and function

immune system
• at 12 months in the cerebellum
• at 18 months

hematopoietic system
• at 12 months in the cerebellum
• at 18 months

Mouse Models of Human Disease
OMIM IDRef(s)
Polyneuropathy, Hearing Loss, Ataxia, Retinitis Pigmentosa, and Cataract; 612674 J:193716