Phenotypes Associated with This Genotype

Genotype
MGI:5486301

• Allelic Composition: Yap1^tm1Hmc/Yap1^tm1Hmc; Six2^{tm1(tTA,tetO-EGFP/cre)Amc}/Six2⁺
• Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Abnormal kidney development in Yap1^tm1Hmc/Yap1^tm1Hmc Six2^{tm1(tTA,tetO-EGFP/cre)Amc}/Six2⁺ mice

mortality/aging

postnatal lethality, complete penetrance ( J:195266 )

• die within 48 hours of birth

renal/urinary system

abnormal kidney cortex morphology ( J:195266 )

• convoluted tubules are not distinguishable in the inner cortex at E18.5

podocyte foot process effacement ( J:195266 )

• seen at P0

abnormal renal glomerulus morphology ( J:195266 )

• few detectable glomeruli

decreased renal glomerulus number ( J:195266 )

• few detectable glomeruli

abnormal kidney development ( J:195266 )

• limited nephrogenesis with abnormal morphogenesis of S shaped bodies at E13.5

• dramatic decrease in the number of nascent nephrons (pretubular aggregates, comma shaped bodies, S shaped bodies, and renal vesicles) at E14.5

abnormal metanephros morphology ( J:195266 )

• abnormal morphogenesis of S shaped bodies at E13.5

• dramatic decrease in the number of nascent nephrons (pretubular aggregates, comma shaped bodies, S shaped bodies, and renal vesicles) at E14.5

• dramatic decrease in the number of cap mesenchyme derived structures that reach the S shaped bodies

• at E14.5 the connecting segment where the S shaped body connects to the ureteric epithelium is abnormal and the distal segment fails to correctly merge with the outermost edge of the ureteric bud

• slight reduction in proliferation in the proximal part of the renal vesicle and the distal part of the S shaped bodies

abnormal nephrogenic zone morphology ( J:195266 )

• reduced nephrogenic zone at E18.5

abnormal kidney medulla morphology ( J:195266 )

• the medulla is mainly composed of collecting ducts at E18.5 suggesting a decrease in the formation of loops of Henle

abnormal kidney papilla morphology ( J:195266 )

• small papilla at E18.5

renal hypoplasia ( J:195266 )

• at P0

abnormal renal tubule morphology ( J:195266 )

• convoluted tubules are not distinguishable in the inner cortex at E18.5

abnormal loop of Henle morphology ( J:195266 )

• defects in formation

abnormal proximal convoluted tubule morphology ( J:195266 )

• few detectable proximal tubules are present

decreased renal tubule number ( J:195266 )

• few detectable proximal tubules are present

impaired branching involved in ureteric bud morphogenesis ( J:195266 )

• decrease in the number of ureteric bud tips at E16.5 and P0 but not at E14.5

anuria ( J:195266 )

• neonatal mice have an empty bladder suggesting a failure to produce urine