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Phenotypes Associated with This Genotype
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phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• baseline extracellular dopamine is decreased in the ventral striatum
• at 6 weeks, the lateral ventricles are enlarged in volume
• at 6 weeks, the normal asymmetry between the left and right lateral ventricles is lost or even reversed
• T2-weighted right value for the thalamus is increased compared to in wild-type mice
• increase in the levels of dopamine D2 receptor in the striatum
• dopamine transporter is increased in the striatum
• a significant, but modest, reduction in parvalbumin, but not calbindin, immunoreactivity in the medial prefrontal cortex at 3 months of age, indicating abnormal neural synchrony in this region
• when prepulse is 74 dB, prepulse inhibition is reduced compared to in wild-type mice

• mice take longer to find hidden food pellets
• however, mice do not display anxiety-associated behaviors, and exhibit normal spatial learning and memory in the Morris water maze, working memory in a Y-maze, and social interactions
• mutants exhibit increased sensitivity to metamphetamine, showing a greater augmentation in locomotion compared to wild-type littermates
• mice exhibit immobility when forced to swim
• mice places in an open field for 2 hours exhibit hyperactivity predominantly in the second hour

• baseline extracellular dopamine is decreased in the ventral striatum
• mutants exhibit increased sensitivity to metamphetamine, showing a higher increase in extracellular dopamine in the ventral striatum compared to wild-type littermates

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
schizophrenia DOID:5419 OMIM:181500
J:124683 , J:194985

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.11
The Jackson Laboratory