Mouse Genome Informatics
tg
    Tg(Camk2a-DISC1)37Asaw/0
C57BL/6-Tg(Camk2a-DISC1)37Asaw
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
nervous system
• baseline extracellular dopamine is decreased in the ventral striatum
• at 6 weeks, the lateral ventricles are enlarged in volume (J:124683)
• at 6 weeks, the normal asymmetry between the left and right lateral ventricles is lost or even reversed (J:124683)
• T2-weighted right value for the thalamus is increased compared to in wild-type mice (J:124683)
• increase in the levels of dopamine D2 receptor in the striatum
• dopamine transporter is increased in the striatum
• a significant, but modest, reduction in parvalbumin, but not calbindin, immunoreactivity in the medial prefrontal cortex at 3 months of age, indicating abnormal neural synchrony in this region
• when prepulse is 74 dB, prepulse inhibition is reduced compared to in wild-type mice (J:124683)

behavior/neurological
• mice take longer to find hidden food pellets (J:124683)
• however, mice do not display anxiety-associated behaviors, and exhibit normal spatial learning and memory in the Morris water maze, working memory in a Y-maze, and social interactions (J:124683)
• mutants exhibit increased sensitivity to metamphetamine, showing a greater augmentation in locomotion compared to wild-type littermates
• mice exhibit immobility when forced to swim (J:124683)
• mice places in an open field for 2 hours exhibit hyperactivity predominantly in the second hour (J:124683)

homeostasis/metabolism
• baseline extracellular dopamine is decreased in the ventral striatum
• mutants exhibit increased sensitivity to metamphetamine, showing a higher increase in extracellular dopamine in the ventral striatum compared to wild-type littermates

Mouse Models of Human Disease
OMIM IDRef(s)
Schizophrenia 9; SCZD9 604906 J:194985
Schizophrenia; SCZD 181500 J:124683