Phenotypes Associated with This Genotype

Genotype
MGI:5485404

• Allelic Composition: Hdac1^tm1.1Shmc/Hdac1^tm1.1Shmc; Hdac2^tm1.1Shmc/Hdac2⁺; Tg(Lck-cre)1Cwi/0
• Genetic Background: involves: 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:194769 )

• all mice die at an average of 15 weeks

immune system

enlarged thymus ( J:194769 )

• in diseased mice

thymus hypoplasia ( J:194769 )

• 5-fold reduction in cellularity in neonates

enlarged spleen ( J:194769 )

• in diseased mice

increased double-negative T cell number ( J:194769 )

• in the percentage but not the absolute numbers

decreased double-positive T cell number ( J:194769 )

increased double-positive T cell number ( J:194769 )

• increase in CD4^low/CD8^high cells at 6 to 8 weeks

arrested T cell differentiation ( J:194769 )

• block at the double negative to double positive transition

decreased CD4-positive, alpha-beta T cell number ( J:194769 )

decreased CD8-positive, alpha-beta T cell number ( J:194769 )

increased single-positive T cell number ( J:194769 )

• 4-fold increase in the percent of immature single positive cells at 6 to 8 weeks

neoplasm

increased tumor incidence ( J:194769 )

• in 1 of 8 mice

growth/size/body

enlarged chest ( J:194769 )

• in moribund mice

distended abdomen ( J:194769 )

• in moribund mice

enlarged spleen ( J:194769 )

• in diseased mice

respiratory system

increased pulmonary respiratory rate ( J:194769 )

• in moribund mice

hematopoietic system

enlarged thymus ( J:194769 )

• in diseased mice

thymus hypoplasia ( J:194769 )

• 5-fold reduction in cellularity in neonates

enlarged spleen ( J:194769 )

• in diseased mice

increased double-negative T cell number ( J:194769 )

• in the percentage but not the absolute numbers

decreased double-positive T cell number ( J:194769 )

increased double-positive T cell number ( J:194769 )

• increase in CD4^low/CD8^high cells at 6 to 8 weeks

arrested T cell differentiation ( J:194769 )

• block at the double negative to double positive transition

decreased CD4-positive, alpha-beta T cell number ( J:194769 )

decreased CD8-positive, alpha-beta T cell number ( J:194769 )

increased single-positive T cell number ( J:194769 )

• 4-fold increase in the percent of immature single positive cells at 6 to 8 weeks

endocrine/exocrine glands

enlarged thymus ( J:194769 )

• in diseased mice

thymus hypoplasia ( J:194769 )

• 5-fold reduction in cellularity in neonates