Phenotypes Associated with This Genotype

Genotype
MGI:5485403

• Allelic Composition: Hdac1^tm1.1Shmc/Hdac1^tm1.1Shmc; Hdac2^tm1.1Shmc/Hdac2^tm1.1Shmc; Tg(Lck-cre)1Cwi/0
• Genetic Background: involves: 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:194769 )

• all mice die at an average of 15 weeks

immune system

increased thymocyte apoptosis ( J:194769 )

• in neonates and at 6 weeks

increased T cell proliferation ( J:194769 )

• in the thymus and spleen

abnormal thymus corticomedullary boundary morphology ( J:194769 )

• effacement of medullary and cortical substructures in diseased thymus

enlarged thymus ( J:194769 )

• massively in diseased mice due to overpopulation with immature and double positive T cells

decreased thymocyte number ( J:194769 )

• 2-fold reduction in mature TCRbeta^high/CD5^high thymocytes at 10 to 14 days

increased thymocyte number ( J:194769 )

• 3-fold increase immature TCRbeta^int/CD5^low thymocytes at 10 to 14 days

increased T cell derived lymphoma incidence ( J:194769 )

enlarged spleen ( J:194769 )

• massively in diseased mice due to overpopulation with immature and double positive T cells

decreased double-positive T cell number ( J:194769 )

• 2.6-fold reduction at 10 to 14 days

increased double-positive T cell number ( J:194769 )

• increase in CD4^low/CD8^high cells at 6 to 8 weeks

• 10-fold increase in absolute number of CD4^low/CD8^high cells at 10 to 14 days

arrested T cell differentiation ( J:194769 )

• block at the double negative to double positive transition

• defects in positive selection and CD4 lineage commitment

increased single-positive T cell number ( J:194769 )

• 4-fold increase in the percent of immature single positive cells at 6 to 8 weeks

neoplasm

increased tumor incidence ( J:194769 )

• with general hyperproliferation of immature T cells and infiltration into nonlymphatic organs (lung, liver and kidney)

increased T cell derived lymphoma incidence ( J:194769 )

growth/size/body

enlarged chest ( J:194769 )

• in moribund mice

distended abdomen ( J:194769 )

• in moribund mice

enlarged spleen ( J:194769 )

• massively in diseased mice due to overpopulation with immature and double positive T cells

respiratory system

increased pulmonary respiratory rate ( J:194769 )

• in moribund mice

cellular

aneuploidy ( J:194769 )

• in tumor cells

trisomy ( J:194769 )

• in tumor cells

increased thymocyte apoptosis ( J:194769 )

• in neonates and at 6 weeks

increased T cell proliferation ( J:194769 )

• in the thymus and spleen

chromosomal instability ( J:194769 )

• in tumorigenic T cells

hematopoietic system

increased thymocyte apoptosis ( J:194769 )

• in neonates and at 6 weeks

increased T cell proliferation ( J:194769 )

• in the thymus and spleen

abnormal thymus corticomedullary boundary morphology ( J:194769 )

• effacement of medullary and cortical substructures in diseased thymus

enlarged thymus ( J:194769 )

• massively in diseased mice due to overpopulation with immature and double positive T cells

decreased thymocyte number ( J:194769 )

• 2-fold reduction in mature TCRbeta^high/CD5^high thymocytes at 10 to 14 days

increased thymocyte number ( J:194769 )

• 3-fold increase immature TCRbeta^int/CD5^low thymocytes at 10 to 14 days

increased T cell derived lymphoma incidence ( J:194769 )

enlarged spleen ( J:194769 )

• massively in diseased mice due to overpopulation with immature and double positive T cells

decreased double-positive T cell number ( J:194769 )

• 2.6-fold reduction at 10 to 14 days

increased double-positive T cell number ( J:194769 )

• increase in CD4^low/CD8^high cells at 6 to 8 weeks

• 10-fold increase in absolute number of CD4^low/CD8^high cells at 10 to 14 days

arrested T cell differentiation ( J:194769 )

• block at the double negative to double positive transition

• defects in positive selection and CD4 lineage commitment

increased single-positive T cell number ( J:194769 )

• 4-fold increase in the percent of immature single positive cells at 6 to 8 weeks

endocrine/exocrine glands

increased thymocyte apoptosis ( J:194769 )

• in neonates and at 6 weeks

abnormal thymus corticomedullary boundary morphology ( J:194769 )

• effacement of medullary and cortical substructures in diseased thymus

enlarged thymus ( J:194769 )

• massively in diseased mice due to overpopulation with immature and double positive T cells

decreased thymocyte number ( J:194769 )

• 2-fold reduction in mature TCRbeta^high/CD5^high thymocytes at 10 to 14 days

increased thymocyte number ( J:194769 )

• 3-fold increase immature TCRbeta^int/CD5^low thymocytes at 10 to 14 days

increased T cell derived lymphoma incidence ( J:194769 )