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Phenotypes Associated with This Genotype
Genotype
MGI:5484740
Allelic
Composition		 Mc4rtm1Lowl/Mc4rtm1Lowl
Chattm1(cre)Lowl/Chat+
Genetic
Background		 involves: 129S4/SvJae * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chattm1(cre)Lowl mutation (1 available); any Chat mutation (63 available)
Mc4rtm1Lowl mutation (2 available); any Mc4r mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
hypertension ( J:193452 )
• develop obesity induced hypertension but only during active period

homeostasis/metabolism
increased circulating insulin level ( J:193452 )
• higher plasma insulin levels

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory