Phenotypes for Pdx1 Stk11 MGI:5484546 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Pdx1^tm1Egs/Pdx1⁺ Stk11^tm1.1Gne/Stk11^tm1.1Gne
Genetic Background	involves: 129S1/Sv * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdx1^tm1Egs mutation (2 available); any Pdx1 mutation (37 available)
Stk11^tm1.1Gne mutation (0 available); any Stk11 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

pancreas cyst ( J:195229 )

• dynamic and AMPK-independent cyst formation in late, but not early, stage pancreas explants treated with 1NMPP1

• pancreatic cysts induced by treatment with 1NMPP1 evolve into precancerous-like lesions without loss of cell polarity

cellular

increased cell proliferation ( J:195229 )

• increased epithelial cell proliferation accompanies pancreatic cyst formation in 1NMPP1-treated pancreatic explants

growth/size/body

pancreas cyst ( J:195229 )

• dynamic and AMPK-independent cyst formation in late, but not early, stage pancreas explants treated with 1NMPP1

• pancreatic cysts induced by treatment with 1NMPP1 evolve into precancerous-like lesions without loss of cell polarity

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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