About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5478730
Allelic
Composition
Npm1tm1Hft/Npm1+
Genetic
Background
involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Npm1tm1Hft mutation (0 available); any Npm1 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Splenomegaly and follicle structure changes in Npm1tm1Hft/Npm1+ mice

growth/size/body
• in mice with myeloproliferative disease
• in mice with myeloproliferative disease

hematopoietic system
N
• mice exhibit normal red cell volumes, red blood cell count, hemoglobin and mean platelet volume
• mice without MPD exhibit increased granulocyte-macrophage progenitors compared with wild-type mice
• in mice with myeloproliferative disease
• in mice with myeloproliferative disease
• some mice exhibit myeloproliferative disease (MPD) features
• mice without MPD exhibit still myeloid expansion
• in mice with myeloproliferative disease with megakaryocyte infiltration
• the bone marrow of mice without MPD exhibits expansion of myeloid compartment with an increase in HSPC and progenitor cells compared with wild-type mice
• mice with or without MPD exhibit age-dependent compromised cobblestone area formation compared with wild-type cells
• increased colony forming units from the bone marrow of mice with MPD
• increased progenitor cells in the bone marrow of mice without MPD
• in some mice late in life
• in some mice at various stages
• mature granulocytes in in the blood and bone marrow of mice with myeloproliferative disease
• in the peripheral blood of mice without MPD after age 17 to 18 months
• in the bone marrow of mice without MPD
• mice with myeloproliferative disease exhibit effacement of follicle structure in the spleen

immune system
• mice without MPD exhibit increased granulocyte-macrophage progenitors compared with wild-type mice
• in mice with myeloproliferative disease
• in mice with myeloproliferative disease
• some mice exhibit myeloproliferative disease (MPD) features
• mice without MPD exhibit still myeloid expansion
• in some mice at various stages
• mature granulocytes in in the blood and bone marrow of mice with myeloproliferative disease
• in the peripheral blood of mice without MPD after age 17 to 18 months
• mice with myeloproliferative disease exhibit effacement of follicle structure in the spleen

cellular
• mice without MPD exhibit increased granulocyte-macrophage progenitors compared with wild-type mice

neoplasm
N
• mice do not develop acute myeloid leukemia

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
NOT acute myeloid leukemia DOID:9119 OMIM:601626
J:194999


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/27/2022
MGI 6.21
The Jackson Laboratory