Phenotypes Associated with This Genotype

Genotype
MGI:5478604

• Allelic Composition: Cdcp1^tm1.2Moas/Cdcp1^tm1.2Moas; Gt(ROSA)26Sor^{tm1(Smo/EYFP)Amc}/Gt(ROSA)26Sor⁺; Tg(KRT14-cre/ERT)20Efu/0
• Genetic Background: involves: 129X1/SvJ * C57BL/6 * CD-1 * FVB/N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:194368 )

• euthanized 12 weeks after tamoxifen-treatment

integument

focal hair loss ( J:194368 )

• in tamoxifen-treated mice, particularly evident on the abdominal skin

abnormal skin morphology ( J:194368 )

• tamoxifen-treated mice develop more severe epidermal disease (thick skin, hair loss and scaling) compared with control mice

thick epidermis ( J:194368 )

• 3.5-fold in tamoxifen-treated mice than in control mice

abnormal skin condition ( J:194368 )

• in tamoxifen-treated mice, particularly evident on the abdominal skin

thick skin ( J:194368 )

• in tamoxifen-treated mice

neoplasm

increased tumor growth/size ( J:194368 )

• accelerated neoplasm development in tamoxifen-treated mice compared with control mice

increased tumor incidence ( J:194368 )

• accelerated neoplasm development in tamoxifen-treated mice compared with control mice

behavior/neurological

hunched posture ( J:194368 )

• in tamoxifen-treated mice