Phenotypes Associated with This Genotype

Genotype
MGI:5478556

• Allelic Composition: G6pc1^tm1.1Ics/G6pc1^tm1.1Ics; Alb^{tm1(cre/ERT2)Mtz}/Alb⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:195257 )

N • unlike in global knock-out mice, glycogen accumulation is not observed in the kidney or intestine of tamoxifen-treated mice

abnormal blood homeostasis ( J:195257 )

• increased serum lactic acid in tamoxifen-treated mice after 10 day or 1 month

• however, levels are normal at 6 and 18 months

increased blood uric acid level ( J:195257 )

• 3-fold in tamoxifen-treated mice after 10 day or 1 month

• however, levels are normal at 6 and 18 months

increased circulating cholesterol level ( J:195257 )

• twice as high in tamoxifen-treated mice

increased circulating triglyceride level ( J:195257 )

• 3-fold in tamoxifen-treated mice

• however, levels at 18 months are normal

increased liver glycogen level ( J:195257 )

• in tamoxifen-treated mice

increased liver triglyceride level ( J:195257 )

• in tamoxifen-treated mice

liver/biliary system

enlarged liver ( J:195257 )

• in tamoxifen-treated mice

increased liver weight ( J:195257 )

• in tamoxifen-treated mice

increased liver glycogen level ( J:195257 )

• in tamoxifen-treated mice

increased liver triglyceride level ( J:195257 )

• in tamoxifen-treated mice

abnormal hepatocyte morphology ( J:195257 )

• large hepatocyte containing large lipid vacuoles in tamoxifen-treated mice

hepatic steatosis ( J:195257 )

• in tamoxifen-treated mice

pale liver ( J:195257 )

• in tamoxifen-treated mice

increased liver adenoma incidence ( J:195257 )

• in tamoxifen-treated mice after a year

• however, no hepatocellular carcinoma is observed

neoplasm

increased liver adenoma incidence ( J:195257 )

• in tamoxifen-treated mice after a year

• however, no hepatocellular carcinoma is observed

growth/size/body

enlarged liver ( J:195257 )

• in tamoxifen-treated mice

increased liver weight ( J:195257 )

• in tamoxifen-treated mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
glycogen storage disease Ia		DOID:2749	OMIM:232200	J:195257