Phenotypes for Fas Tlr7 MGI:5478501 MGI Mouse

decreased double-negative T cell number ( J:113557 )

• decrease in accumulation of double-negative T cells in the spleen compared to Fas^lpr homozygotes

abnormal CD4-positive, alpha beta T cell morphology ( J:113557 )

• decrease in proportion of CD4+ T cells expressing CD44, both in the lymph node and spleen compared to Fas^lpr homozygotes

decreased spleen weight ( J:113557 )

• spleen weight is decreased compared to Fas^lpr homozygotes

abnormal B cell activation ( J:113557 )

• general B cell activation is inhibited compared to Fas^lpr homozygotes, as indicated by decreased CD44 expression in splenic B cells

decreased IgG2a level ( J:113557 )

• serum IgG2a levels are decreased compared to Fas^lpr homozygotes

decreased IgG3 level ( J:113557 )

• serum IgG3 levels are decreased compared to Fas^lpr homozygotes

abnormal lymph node size ( J:113557 )

• lymph node weight is decreased compared to Fas^lpr homozygotes

abnormal plasmacytoid dendritic cell physiology ( J:113557 )

• plasmacytoid DCs exhibit a more immature phenotype compared to Fas^lpr homozygotes, with decreased expression of MHC class II

decreased susceptibility to systemic lupus erythematosus ( J:113557 )

• renal disease is significantly decreased compared to Fas^lpr homozygotes, with mice showing decreased glomerular protein deposition and preserved glomerular structure

• although skin disease is evident in mutants, it occurs with a very low frequency and very little is seen at 16 weeks of age

decreased autoantibody level ( J:113557 )

• mutants exhibit impaired generation of antibodies to RNA complexes and generation of high-titer Smith antibodies is blocked

increased autoantibody level ( J:113557 )

• DNA autoantibodies are seen in mutants

increased anti-chromatin antibody level ( J:113557 )