Phenotypes Associated with This Genotype

Genotype
MGI:5476732

• Allelic Composition: Il1rl2^tm1Hblu/Il1rl2^tm1Hblu
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Il1rl2^tm1Hblu/Il1rl2^tm1Hblu and Il36rn^tm1Kopf/Il36rn^tm1Kopf mice show different susceptibilities to IMQ-induced psoriasiform dermatitis

digestive/alimentary system

decreased susceptibility to induced colitis ( J:256437 )

• mice treated with the hapten oxazolone to induce colitis (a TH2/9 model of colitis) show reduced weight loss and colonic inflammation compared to wild-type mice

immune system

decreased susceptibility to induced colitis ( J:256437 )

• mice treated with the hapten oxazolone to induce colitis (a TH2/9 model of colitis) show reduced weight loss and colonic inflammation compared to wild-type mice

increased regulatory T cell number ( J:256437 )

• following oxazolone-induced colitis, mice show increased frequency and absolute number of Helios-Foxp3+CD4+ T cells in colonic tissue indicating increased colonic T-reg cells

decreased leukocyte cell number ( J:193548 )

• in the skin of IMQ-treated mice

decreased neutrophil cell number ( J:193548 )

• in the skin of IMQ-treated mice

• in skin-draining lymph nodes of IMQ-treated mice

decreased gamma-delta T cell number ( J:193548 )

• decreased IL17A-producing gamma-delta T cells in IMQ-treated mice

decreased macrophage cell number ( J:193548 )

• in skin-draining lymph nodes of IMQ-treated mice

abnormal lymph node morphology ( J:193548 )

• reduced cellularity of skin-draining lymph nodes of IMQ-treated mice

decreased interleukin-17 secretion ( J:193548 )

• decreased IL17A-producing gamma-delta T cells in IMQ-treated mice

decreased interleukin-9 secretion ( J:256437 )

• following oxazolone-induced colitis, mice show reduced IL-9 production by colonic lamina propria lymphocytes

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:193548 )

• mice are protected from IMQ (Aldara)-induced psoriasis with decreased ear swelling, acanthosis, erythema, skin flaking and hyperkeratosis compared with wild-type mice

hematopoietic system

increased regulatory T cell number ( J:256437 )

• following oxazolone-induced colitis, mice show increased frequency and absolute number of Helios-Foxp3+CD4+ T cells in colonic tissue indicating increased colonic T-reg cells

decreased leukocyte cell number ( J:193548 )

• in the skin of IMQ-treated mice

decreased neutrophil cell number ( J:193548 )

• in the skin of IMQ-treated mice

• in skin-draining lymph nodes of IMQ-treated mice

decreased gamma-delta T cell number ( J:193548 )

• decreased IL17A-producing gamma-delta T cells in IMQ-treated mice

decreased macrophage cell number ( J:193548 )

• in skin-draining lymph nodes of IMQ-treated mice