Phenotypes Associated with This Genotype

Genotype
MGI:5475000

• Allelic Composition: Rr166^tm4.1Wtg/Rr166^tm4.1Wtg
• Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal B cell differentiation ( J:193015 )

abnormal immunoglobulin light chain V-J recombination ( J:193015 )

• dramatic increase in usage of proximal Vkappa genes as opposed to more distal ones

• increased usage of Jkappa1 and decreased usage of Jkappa2

abnormal pre-B cell morphology ( J:193015 )

• pre-B cells show a less contracted and non-looped pattern in the nucleus

abnormal B cell physiology ( J:193015 )

• slightly increased percentage of Ig kappa expressing B cells

abnormal immunoglobulin level ( J:193015 )

• slightly increased percentage of Ig kappa expressing B cells

• dramatic increase in usage of proximal Vkappa genes as opposed to more distal ones

• increased usage of Jkappa1 and decreased usage of Jkappa2

hematopoietic system

abnormal B cell differentiation ( J:193015 )

abnormal immunoglobulin light chain V-J recombination ( J:193015 )

• dramatic increase in usage of proximal Vkappa genes as opposed to more distal ones

• increased usage of Jkappa1 and decreased usage of Jkappa2

abnormal pre-B cell morphology ( J:193015 )

• pre-B cells show a less contracted and non-looped pattern in the nucleus

abnormal B cell physiology ( J:193015 )

• slightly increased percentage of Ig kappa expressing B cells

abnormal immunoglobulin level ( J:193015 )

• slightly increased percentage of Ig kappa expressing B cells

• dramatic increase in usage of proximal Vkappa genes as opposed to more distal ones

• increased usage of Jkappa1 and decreased usage of Jkappa2