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Phenotypes Associated with This Genotype
Genotype
MGI:5474862
Allelic
Composition		 Lrattm1Kpal/Lrattm1Kpal
Rhotm2.1Kpal/Rhotm2.1Kpal
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrattm1Kpal mutation (1 available); any Lrat mutation (26 available)
Rhotm2.1Kpal mutation (0 available); any Rho mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Severe retinal degeneration in Rhotm2.1Kpal/Rhotm2.1Kpal Gnat1tm1Clma/Gnat1tm1Clma mice and less severe degeneration in Rhotm2.1Kpal/Rhotm2.1Kpal Lrattm1Kpal/Lrattm1Kpal mice

vision/eye
retina photoreceptor degeneration ( J:194158 )
• less severe than in Rhotm2.1Kpal homozygotes
thin retina outer nuclear layer ( J:194158 )
• less severe than in Rhotm2.1Kpal homozygotes

nervous system
retina photoreceptor degeneration ( J:194158 )
• less severe than in Rhotm2.1Kpal homozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory