Phenotypes Associated with This Genotype

Genotype
MGI:5474783

• Allelic Composition: Ezh1^tm1Sgon/Ezh1^tm1Sgon; Tg(VAV1-cre)1Graf/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:193722 )

N • mice exhibit normal numbers of myeloid progenitors and colony-forming cells

N • mice exhibit normal fetal hematopoiesis

decreased pro-B cell number ( J:193722 )

decreased bone marrow cell number ( J:193722 )

• 2-fold reduction in bone marrow cellularity with 2-fold fewer side population cells

abnormal common lymphocyte progenitor cell morphology ( J:193722 )

• reduced mature lymphoid progenitor pools

decreased B cell number ( J:193722 )

• in the peripheral blood

decreased immature B cell number ( J:193722 )

decreased hematopoietic stem cell number ( J:193722 )

• long term, short term and multipotent progenitors with 2-fold fewer side population cells

abnormal myeloid leukocyte morphology ( J:193722 )

• slight decrease in the peripheral blood

decreased spleen red pulp amount ( J:193722 )

small spleen ( J:193722 )

absent spleen germinal center ( J:193722 )

decreased spleen white pulp amount ( J:193722 )

abnormal bone marrow cell physiology ( J:193722 )

• bone marrow failure is hematopoietic cell autonomous

abnormal hematopoietic stem cell physiology ( J:193722 )

• long term and short term hematopoietic stem cells/ multipotent progenitors exhibit reduced cell cycling and senescence compared with control cells

• hematopoietic stem cells (HSCs) are unable to engraft tertiary recipients

• in transplant experiments, HSCs exhibit defective homing in the bone marrow

• bone marrow failure is hematopoietic cell autonomous

cellular

early cellular replicative senescence ( J:193722 )

• in hematopoietic stem cell

immune system

decreased pro-B cell number ( J:193722 )

decreased B cell number ( J:193722 )

• in the peripheral blood

decreased immature B cell number ( J:193722 )

abnormal myeloid leukocyte morphology ( J:193722 )

• slight decrease in the peripheral blood

decreased spleen red pulp amount ( J:193722 )

small spleen ( J:193722 )

absent spleen germinal center ( J:193722 )

decreased spleen white pulp amount ( J:193722 )

lymphoid hypoplasia ( J:193722 )

• in the spleen