Phenotypes Associated with This Genotype

Genotype
MGI:5474455

• Allelic Composition: Slc20a1^tm1.1Lbek/Slc20a1^tm1.1Lbek; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

enlarged spleen ( J:194198 )

• in pIpC-treated mice

spleen hyperplasia ( J:194198 )

• in pIpC-treated mice

abnormal definitive hematopoiesis ( J:194198 )

• in an in vitro hematopoietic progenitor assay, spleen samples from pIpC-treated mice produce more granulocyte/macrophages, erythroid cells and immature red blood cells compared with wild-type spleen samples

decreased erythrocyte cell number ( J:194198 )

• in pIpC-treated mice

increased leukocyte cell number ( J:194198 )

• in pIpC-treated mice

intermingled spleen red and white pulp ( J:194198 )

• in pIpC-treated mice

immune system

enlarged spleen ( J:194198 )

• in pIpC-treated mice

spleen hyperplasia ( J:194198 )

• in pIpC-treated mice

increased leukocyte cell number ( J:194198 )

• in pIpC-treated mice

intermingled spleen red and white pulp ( J:194198 )

• in pIpC-treated mice

growth/size/body

enlarged spleen ( J:194198 )

• in pIpC-treated mice

spleen hyperplasia ( J:194198 )

• in pIpC-treated mice