Phenotypes Associated with This Genotype

Genotype
MGI:5474354

• Allelic Composition: Gt(ROSA)26Sor^tm2Jake/Gt(ROSA)26Sor⁺; Tg(Gfap-cre)#Mvs/0
• Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6NHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal response to injury ( J:192021 )

• at 14 days post injury, astrocytes adjacent to spinal cord lesions are larger and have thicker processes compared to astrocytes in injured wild-type mice

• however, lesion size is similar to that in injured wild-type mice

• at 35 days post injury astrocytes adjacent to the injury site remain hypertrophic unlike in wild-type controls

• increase in the number of axons present within the injury site

nervous system

abnormal astrocyte morphology ( J:192021 )

• at 14 days post injury, astrocytes adjacent to spinal cord lesions are larger and have thicker processes compared to astrocytes in injured wild-type mice

• at 35 days post injury astrocytes adjacent to the injury site remain hypertrophic unlike in wild-type controls

abnormal astrocyte physiology ( J:192021 )

• at 14 days post spinal injury formation of reactive astrocytes is increased compared to injured wild-type controls

cellular

abnormal astrocyte morphology ( J:192021 )

• at 14 days post injury, astrocytes adjacent to spinal cord lesions are larger and have thicker processes compared to astrocytes in injured wild-type mice

• at 35 days post injury astrocytes adjacent to the injury site remain hypertrophic unlike in wild-type controls

abnormal astrocyte physiology ( J:192021 )

• at 14 days post spinal injury formation of reactive astrocytes is increased compared to injured wild-type controls