Phenotypes Associated with This Genotype

Genotype
MGI:5474202

• Allelic Composition: Cd3e^tm1.1Geno/Cd3e^tm1.1Geno; Tg(TcraTcrb)1100Mjb/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal thymus cell ratio ( J:192604 )

• strong decrease in the population of DP cells expressing high levels of CD4 and CD8 with thymocytes accumulating at intermediate stages of differentiation from DP to CD8 single positive

• thymocytes accumulate at the DP3 stage

abnormal T cell differentiation ( J:192604 )

• thymocytes accumulate at intermediate stages of differentiation from DP to CD8 single positive indicating a partial arrest beyond the positive selection checkpoint

• thymocytes accumulate at the DP3 stage

• partial arrest at the DN3 stage

increased DN3 thymocyte number ( J:192604 )

abnormal positive T cell selection ( J:192604 )

• expression analysis indicates a defect in positive selection

decreased double-positive T cell number ( J:192604 )

• strong decrease in the population of DP cells expressing high levels of CD4 and CD8

decreased T cell number ( J:192604 )

• decrease in the absolute number of thymocytes

hematopoietic system

abnormal thymus cell ratio ( J:192604 )

• strong decrease in the population of DP cells expressing high levels of CD4 and CD8 with thymocytes accumulating at intermediate stages of differentiation from DP to CD8 single positive

• thymocytes accumulate at the DP3 stage

abnormal T cell differentiation ( J:192604 )

• thymocytes accumulate at intermediate stages of differentiation from DP to CD8 single positive indicating a partial arrest beyond the positive selection checkpoint

• thymocytes accumulate at the DP3 stage

• partial arrest at the DN3 stage

increased DN3 thymocyte number ( J:192604 )

abnormal positive T cell selection ( J:192604 )

• expression analysis indicates a defect in positive selection

decreased T cell number ( J:192604 )

• decrease in the absolute number of thymocytes

decreased double-positive T cell number ( J:192604 )

• strong decrease in the population of DP cells expressing high levels of CD4 and CD8

endocrine/exocrine glands

abnormal thymus cell ratio ( J:192604 )

• strong decrease in the population of DP cells expressing high levels of CD4 and CD8 with thymocytes accumulating at intermediate stages of differentiation from DP to CD8 single positive

• thymocytes accumulate at the DP3 stage

increased DN3 thymocyte number ( J:192604 )