Phenotypes Associated with This Genotype

Genotype
MGI:5473581

• Allelic Composition: Foxo6^tm1Abru/Foxo6^tm1Abru
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:191193 )

N • mice exhibit normal motor coordination, conditioned learning and spatial memory

abnormal temporal memory ( J:191193 )

• mice exhibit defects in consolidation of fear memory in a tone- and context-cued conditioning tests after 24 and 48 hours, respectively, compared with wild-type mice

• however, learning of the conditioned behavior is normal

impaired long-term object recognition memory ( J:191193 )

• impaired after 24 hours

increased grooming behavior ( J:191193 )

decreased locomotor activity ( J:191193 )

• slightly

nervous system

decreased dendritic spine density ( J:191193 )

• decreased dendritic spine density due to a decrease in spine number

increased dendritic spine length ( J:191193 )

• spine length is increased

decreased dendritic spine number ( J:191193 )

• decreased dendritic spine density due to a decrease in spine number

abnormal brain wave pattern ( J:191193 )

• during novel object learning, mice exhibit impaired neuronal synchronization in the hippocampus compared with wild-type mice