Foxo6^tm1Abru
Targeted Allele Detail

Summary

• Symbol: Foxo6^tm1Abru
• Name: forkhead box O6; targeted mutation 1, Anne Brunet
• MGI ID: MGI:5473578
• Gene: Foxo6 Location: Chr4:120124275-120144458 bp, - strand Genetic Position: Chr4, 56.1 cM
• Alliance: Foxo6^tm1Abru page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:191193
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette replaced exon 1. Western blot analysis confirmed the absence of protein expression in the anterior brain, cortex and hippocampus. (J:191193)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Foxo6 Mutation: 11 strains or lines available

References

• Original: J:191193 Salih DA, et al., FoxO6 regulates memory consolidation and synaptic function. Genes Dev. 2012 Dec 15;26(24):2780-801
• All: 2 reference(s)