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Phenotypes Associated with This Genotype
Genotype
MGI:5473569
Allelic
Composition		 Msx1tm2.1(cre/ERT2)Bero/Msx1tm2.1(cre/ERT2)Bero
Msx2tm1Bero/Msx2tm1Bero
Genetic
Background		 involves: 129/Sv * 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msx1tm2.1(cre/ERT2)Bero mutation (2 available); any Msx1 mutation (18 available)
Msx2tm1Bero mutation (1 available); any Msx2 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality ( J:194129 )
• animals die during first day following birth likely from denutrition, dehydration or hypothermia

craniofacial
absent teeth ( J:194129 )
• general tooth agenesis observed at autopsy
absent malleus processus brevis ( J:194129 )
• observed at autopsy
cleft secondary palate ( J:194129 )
• observed at autopsy

skeleton
absent teeth ( J:194129 )
• general tooth agenesis observed at autopsy
absent malleus processus brevis ( J:194129 )
• observed at autopsy

digestive/alimentary system
cleft secondary palate ( J:194129 )
• observed at autopsy

hearing/vestibular/ear
absent malleus processus brevis ( J:194129 )
• observed at autopsy

behavior/neurological
absent gastric milk in neonates ( J:194129 )
• newborns have no milk in their stomach, suggesting denutrition/dehydration might be cause of lethality

growth/size/body
absent teeth ( J:194129 )
• general tooth agenesis observed at autopsy
cleft secondary palate ( J:194129 )
• observed at autopsy

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory