Phenotypes Associated with This Genotype

Genotype
MGI:5473569

• Allelic Composition: Msx1^{tm2.1(cre/ERT2)Bero}/Msx1^{tm2.1(cre/ERT2)Bero}; Msx2^tm1Bero/Msx2^tm1Bero
• Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality ( J:194129 )

• animals die during first day following birth likely from denutrition, dehydration or hypothermia

craniofacial

absent teeth ( J:194129 )

• general tooth agenesis observed at autopsy

absent malleus processus brevis ( J:194129 )

• observed at autopsy

cleft secondary palate ( J:194129 )

• observed at autopsy

skeleton

absent teeth ( J:194129 )

• general tooth agenesis observed at autopsy

absent malleus processus brevis ( J:194129 )

• observed at autopsy

digestive/alimentary system

cleft secondary palate ( J:194129 )

• observed at autopsy

hearing/vestibular/ear

absent malleus processus brevis ( J:194129 )

• observed at autopsy

behavior/neurological

absent gastric milk in neonates ( J:194129 )

• newborns have no milk in their stomach, suggesting denutrition/dehydration might be cause of lethality

growth/size/body

absent teeth ( J:194129 )

• general tooth agenesis observed at autopsy

cleft secondary palate ( J:194129 )

• observed at autopsy