Phenotypes Associated with This Genotype

Genotype
MGI:5473526

• Allelic Composition: Pomc^tm2Low/Pomc^tm2Low
• Genetic Background: B6.129S4-Pomc^tm2Low

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating glucose level ( J:194013 )

increased circulating insulin level ( J:194013 )

increased circulating leptin level ( J:194013 )

decreased oxygen consumption ( J:194013 )

insulin resistance ( J:194013 )

adipose tissue

increased total body fat amount ( J:194013 )

increased gonadal fat pad weight ( J:194013 )

increased inguinal fat pad weight ( J:194013 )

increased retroperitoneal fat pad weight ( J:194013 )

behavior/neurological

decreased compensatory feeding amount ( J:194013 )

♂ • following a 24 hour fast in male, but not female, mice

polyphagia ( J:194013 )

decreased locomotor activity ( J:194013 )

growth/size/body

increased lean body mass ( J:194013 )

obese ( J:194013 )

• as early as 5 weeks

• however, mice subjected to caloric restriction exhibit normal weight until removed from caloric restriction

increased liver weight ( J:194013 )

liver/biliary system

increased liver weight ( J:194013 )

hepatic steatosis ( J:194013 )