Phenotypes Associated with This Genotype

Genotype
MGI:5470528

• Allelic Composition: Robo1^tm1Matl/Robo1^tm1Matl; Robo2^tm1Mrt/Robo2^tm1Mrt
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:193400 )

• die within minutes of birth

homeostasis/metabolism

cyanosis ( J:193400 )

respiratory system

short trachea ( J:193400 )

• slightly shorter

respiratory failure ( J:193400 )

• lungs fail to inflate

nervous system

abnormal axon guidance ( J:119469 )

• olfactory bulb axons from E14 explants are not repelled by SLIT proteins

abnormal olfactory tract morphology ( J:119469 )

• highly defasciculated into small axonal bundles fanned all over the ventral side of the telencephalon, at E15.5 and E18

• a subset of axons originating from the lateral bulb are still present in the normal location

abnormal spinal cord ventral commissure morphology ( J:194150 )

• at E11.5, commissural axons exhibit robust postcrossing trajectory defects with failure to project to the lateral portion of the funiculus and altered lateral and ventral funiculi ration compared with wild-type mice

cellular

abnormal axon guidance ( J:119469 )

• olfactory bulb axons from E14 explants are not repelled by SLIT proteins

decreased cell migration ( J:193400 )

• in culture, fewer E10.5 foregut cells migrate away from SLIT2 containing media

digestive/alimentary system

abnormal stomach position or orientation ( J:193400 )

• mispositioning of the stomach in the thoracic instead of the abdominal cavity

• abnormal midline position detected as early as E11.5

• more prominent at E13.5 and disrupts the diaphragm

• located at the midline and protrudes through the esophageal hiatus into the thoracic cavity in neonates

abnormal foregut morphology ( J:193400 )

• delayed separation of the foregut from the body wall

small esophagus ( J:193400 )

• short

esophagus hypoplasia ( J:193400 )

muscle

abnormal diaphragm morphology ( J:193400 )

• malformed

behavior/neurological

absent gastric milk in neonates ( J:193400 )

cardiovascular system

abnormal dorsal aorta morphology ( J:193400 )

• fails to fuse by E11.5