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Phenotypes Associated with This Genotype
Genotype
MGI:5470056
Allelic
Composition
Cbfbtm5Ppl/Cbfb+
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cbfbtm5Ppl mutation (0 available); any Cbfb mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• bone marrow cells from mice treated with ENU produce more granulocyte and macrophage (CFU-GM) colonies compared with wild-type mice
• some aged mice treated with ENU develop myeloproliferative disease with increased Mac1/Gr1+ cells in the peripheral blood
• increased myelopoiesis in the bone marrow and spleen of some aged mice treated with ENU
• however, cells do not exhibit a blast-like appearance and transplanted cells do not result in abnormal myelopoiesis in recipient mice

neoplasm
N
• ENU-treated mice do not develop leukemia

cellular
• bone marrow cells from mice treated with ENU produce more granulocyte and macrophage (CFU-GM) colonies compared with wild-type mice

immune system
• bone marrow cells from mice treated with ENU produce more granulocyte and macrophage (CFU-GM) colonies compared with wild-type mice
• some aged mice treated with ENU develop myeloproliferative disease with increased Mac1/Gr1+ cells in the peripheral blood
• increased myelopoiesis in the bone marrow and spleen of some aged mice treated with ENU
• however, cells do not exhibit a blast-like appearance and transplanted cells do not result in abnormal myelopoiesis in recipient mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory