hematopoietic system
• bone marrow cells from mice treated with ENU produce more granulocyte and macrophage (CFU-GM) colonies compared with wild-type mice
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• some aged mice treated with ENU develop myeloproliferative disease with increased Mac1/Gr1+ cells in the peripheral blood
• increased myelopoiesis in the bone marrow and spleen of some aged mice treated with ENU
• however, cells do not exhibit a blast-like appearance and transplanted cells do not result in abnormal myelopoiesis in recipient mice
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neoplasm
cellular
• bone marrow cells from mice treated with ENU produce more granulocyte and macrophage (CFU-GM) colonies compared with wild-type mice
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immune system
• bone marrow cells from mice treated with ENU produce more granulocyte and macrophage (CFU-GM) colonies compared with wild-type mice
|
• some aged mice treated with ENU develop myeloproliferative disease with increased Mac1/Gr1+ cells in the peripheral blood
• increased myelopoiesis in the bone marrow and spleen of some aged mice treated with ENU
• however, cells do not exhibit a blast-like appearance and transplanted cells do not result in abnormal myelopoiesis in recipient mice
|