Phenotypes Associated with This Genotype

Genotype
MGI:5469975

• Allelic Composition: Scyl1^tm1Spel/Scyl1^tm1Spel; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:192445 )

N • unlike Scyl1^tm1.1Spel homozygotes, mice do not develop tremors and the majority do not become paralyzed

abnormal motor capabilities/coordination/movement ( J:192445 )

• motor dysfunctions develop more slowly and are not as severe as in Scyl1^tm1.1Spel homozygotes

decreased grip strength ( J:192445 )

• by 4 weeks

abnormal locomotor coordination ( J:192445 )

• posterior waddle by 8 weeks

abnormal gait ( J:192445 )

• by 8 weeks

muscle

muscle phenotype ( J:192445 )

N • unlike Scyl1^tm1.1Spel homozygotes, mice do not develop massive muscle wasting

decreased myocardial fiber size ( J:192445 )

centrally nucleated skeletal muscle fibers ( J:192445 )

nervous system

astrocytosis ( J:192445 )

microgliosis ( J:192445 )

decreased motor neuron number ( J:192445 )

• slight

growth/size/body

decreased body weight ( J:192445 )

postnatal growth retardation ( J:192445 )

skeleton

skeleton phenotype ( J:192445 )

N • unlike Scyl1^tm1.1Spel homozygotes, mice do not develop flattening of the pelvis

cardiovascular system

decreased myocardial fiber size ( J:192445 )

hematopoietic system

microgliosis ( J:192445 )

immune system

microgliosis ( J:192445 )

cellular

astrocytosis ( J:192445 )

microgliosis ( J:192445 )