Mouse Genome Informatics
cn
    Pik3catm1Gne/Pik3ca+
Tg(MMTV-cre)1Mam/0

involves: C57BL/6N * FVB
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
tumorigenesis
N
• male mice do not develop tumors in the mammary gland or seminal vesicles
• thoracic and inguino-abdominal mammary gland tumors with latency dependent on nulliparous or multiparous condition
• however, treatment with PI3K inhibitor inhibits tumor growth

integument
• precocious lobulo-alveolar development and hyper-branched ductal structures (2-fold increase in ductal branch point) at 12 weeks
• feathery, hyper-branched ductal tree by 50 weeks

endocrine/exocrine glands
• precocious lobulo-alveolar development and hyper-branched ductal structures (2-fold increase in ductal branch point) at 12 weeks
• feathery, hyper-branched ductal tree by 50 weeks

Mouse Models of Human Disease
OMIM IDRef(s)
Breast Cancer 114480 J:193377