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Phenotypes Associated with This Genotype
Genotype
MGI:5469591
Allelic
Composition
Pik3catm1Gne/Pik3ca+
Tg(MMTV-cre)1Mam/0
Genetic
Background
involves: C57BL/6N * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3catm1Gne mutation (0 available); any Pik3ca mutation (39 available)
Tg(MMTV-cre)1Mam mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
N
• male mice do not develop tumors in the mammary gland or seminal vesicles
• thoracic and inguino-abdominal mammary gland tumors with latency dependent on nulliparous or multiparous condition
• however, treatment with PI3K inhibitor inhibits tumor growth

integument
• precocious lobulo-alveolar development and hyper-branched ductal structures (2-fold increase in ductal branch point) at 12 weeks
• feathery, hyper-branched ductal tree by 50 weeks
• thoracic and inguino-abdominal mammary gland tumors with latency dependent on nulliparous or multiparous condition
• however, treatment with PI3K inhibitor inhibits tumor growth

endocrine/exocrine glands
• precocious lobulo-alveolar development and hyper-branched ductal structures (2-fold increase in ductal branch point) at 12 weeks
• feathery, hyper-branched ductal tree by 50 weeks
• thoracic and inguino-abdominal mammary gland tumors with latency dependent on nulliparous or multiparous condition
• however, treatment with PI3K inhibitor inhibits tumor growth

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
breast cancer DOID:1612 OMIM:114480
OMIM:600048
OMIM:605365
J:193377


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/17/2017
MGI 6.10
The Jackson Laboratory