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Phenotypes Associated with This Genotype
Genotype
MGI:5469012
Allelic
Composition		 Il2rgtm1.1Asin/Il2rgtm1Wjl
Tg(Cd8a*-cre)B8Asin/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2rgtm1.1Asin mutation (1 available); any Il2rg mutation (177 available)
Il2rgtm1Wjl mutation (84 available); any Il2rg mutation (177 available)
Tg(Cd8a*-cre)B8Asin mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased CD8-positive, alpha-beta T cell number ( J:190889 )
• in the thymus but not the periphery due to lymphopenia-induced homeostatic expansion
decreased NK T cell number ( J:190889 )
• of invariant NK T cells in the thymus, spleen and liver
decreased regulatory T cell number ( J:190889 )
• of CD4 single-positive thymocytes expressing Foxp3
• however, these cells are restored by a cross with Tg(LCKprBCL2)36Sjk mice

hematopoietic system
decreased CD8-positive, alpha-beta T cell number ( J:190889 )
• in the thymus but not the periphery due to lymphopenia-induced homeostatic expansion
decreased NK T cell number ( J:190889 )
• of invariant NK T cells in the thymus, spleen and liver
decreased regulatory T cell number ( J:190889 )
• of CD4 single-positive thymocytes expressing Foxp3
• however, these cells are restored by a cross with Tg(LCKprBCL2)36Sjk mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory