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Phenotypes Associated with This Genotype
Genotype
MGI:5465446
Allelic
Composition		 Actl6atm1.1Grc/Actl6a+
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Actl6atm1.1Grc mutation (1 available); any Actl6a mutation (39 available)
Tg(Mx1-cre)1Cgn mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased common myeloid progenitor cell number ( J:192124 )
• in the bone marrow of pIpC-treated mice
decreased granulocyte number ( J:192124 )
• in the bone marrow of pIpC-treated mice
decreased macrophage cell number ( J:192124 )
• in the bone marrow of pIpC-treated mice

immune system
decreased granulocyte number ( J:192124 )
• in the bone marrow of pIpC-treated mice
decreased macrophage cell number ( J:192124 )
• in the bone marrow of pIpC-treated mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory