Mouse Genome Informatics
hm
    Srgap3tm1.1Zi/Srgap3tm1.1Zi
B6.129(SJL)-Srgap3tm1.1Zi
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• some mice from hydrocephalus at a median age of 50 days

behavior/neurological
N
• mice exhibit normal anxiety-associated behavior, fear conditioning, conditioned taste aversion, spatial memory and short-term and long-term memory (J:192388)
• reduced exploration of objects
• mice exhibit decreased spontaneous alteration in a Y-maze compared with wild-type mice
• mice exhibit increased spontaneous tics compared with wild-type mice
• in male, but not female, mice treated with methylphenidate (J:192388)
• male and female mice exhibit reduced anogenital exploration compared with wild-type mice
• female mice exhibit increased social evasion compared with wild-type mice
• female mice exhibit reduced nonanogenital exploration and approach and follow behavior compared with wild-type mice
• however, contact behavior is normal

nervous system
• enlarged white matter tract, most prominent in the corpus callosum with enlargement in the alveus and external capsule
• longer spines in both basal and apical dendrites
• in female mice at high intensity (J:192388)

homeostasis/metabolism
• in male mice (J:192388)
• periventricular edema

Mouse Models of Human Disease
OMIM IDRef(s)
Schizophrenia; SCZD 181500 J:192388