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Phenotypes Associated with This Genotype
Genotype
MGI:5465282
Allelic
Composition
Srgap3tm1.1Zi/Srgap3tm1.1Zi
Genetic
Background
B6.129(SJL)-Srgap3tm1.1Zi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Srgap3tm1.1Zi mutation (0 available); any Srgap3 mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• some mice from hydrocephalus at a median age of 50 days (J:192388)
• some mice from hydrocephalus at a median age of 50 days (J:192388)

behavior/neurological
N
• mice exhibit normal anxiety-associated behavior, fear conditioning, conditioned taste aversion, spatial memory and short-term and long-term memory (J:192388)
• mice exhibit normal anxiety-associated behavior, fear conditioning, conditioned taste aversion, spatial memory and short-term and long-term memory (J:192388)
• reduced exploration of objects (J:192388)
• reduced exploration of objects (J:192388)
• mice exhibit decreased spontaneous alteration in a Y-maze compared with wild-type mice (J:192388)
• mice exhibit decreased spontaneous alteration in a Y-maze compared with wild-type mice (J:192388)
• mice exhibit increased spontaneous tics compared with wild-type mice (J:192388)
• mice exhibit increased spontaneous tics compared with wild-type mice (J:192388)
• in male, but not female, mice treated with methylphenidate (J:192388)
• in male, but not female, mice treated with methylphenidate (J:192388)
• male and female mice exhibit reduced anogenital exploration compared with wild-type mice (J:192388)
• female mice exhibit increased social evasion compared with wild-type mice (J:192388)
• female mice exhibit reduced nonanogenital exploration and approach and follow behavior compared with wild-type mice (J:192388)
• however, contact behavior is normal (J:192388)
• male and female mice exhibit reduced anogenital exploration compared with wild-type mice (J:192388)
• female mice exhibit increased social evasion compared with wild-type mice (J:192388)
• female mice exhibit reduced nonanogenital exploration and approach and follow behavior compared with wild-type mice (J:192388)
• however, contact behavior is normal (J:192388)

nervous system
• enlarged white matter tract, most prominent in the corpus callosum with enlargement in the alveus and external capsule (J:192388)
• enlarged white matter tract, most prominent in the corpus callosum with enlargement in the alveus and external capsule (J:192388)
• longer spines in both basal and apical dendrites (J:192388)
• longer spines in both basal and apical dendrites (J:192388)
• in female mice at high intensity (J:192388)
• in female mice at high intensity (J:192388)

homeostasis/metabolism
• in male mice (J:192388)
• in male mice (J:192388)
• periventricular edema (J:192388)
• periventricular edema (J:192388)

Mouse Models of Human Disease
OMIM ID Ref(s)
Schizophrenia; SCZD 181500 J:192388


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory