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Phenotypes Associated with This Genotype
Genotype
MGI:5465282
Allelic
Composition
Srgap3tm1.1Zi/Srgap3tm1.1Zi
Genetic
Background
B6.129(SJL)-Srgap3tm1.1Zi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Srgap3tm1.1Zi mutation (0 available); any Srgap3 mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• some mice from hydrocephalus at a median age of 50 days

behavior/neurological
N
• mice exhibit normal anxiety-associated behavior, fear conditioning, conditioned taste aversion, spatial memory and short-term and long-term memory
• mice exhibit decreased spontaneous alteration in a Y-maze compared with wild-type mice
• reduced exploration of objects
• mice exhibit increased spontaneous tics compared with wild-type mice
• in male, but not female, mice treated with methylphenidate
• male and female mice exhibit reduced anogenital exploration compared with wild-type mice
• female mice exhibit increased social evasion compared with wild-type mice
• female mice exhibit reduced nonanogenital exploration and approach and follow behavior compared with wild-type mice
• however, contact behavior is normal

nervous system
• enlarged white matter tract, most prominent in the corpus callosum with enlargement in the alveus and external capsule
• longer spines in both basal and apical dendrites
• in female mice at high intensity

homeostasis/metabolism
• periventricular edema

Mouse Models of Human Disease
OMIM ID Ref(s)
Schizophrenia; SCZD 181500 J:192388


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory