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Phenotypes Associated with This Genotype
Genotype
MGI:5464999
Allelic
Composition		 Hif1atm3Rsjo/Hif1atm3Rsjo
Tg(Tal1-cre/ERT)42-056Jrg/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hif1atm3Rsjo mutation (3 available); any Hif1a mutation (48 available)
Tg(Tal1-cre/ERT)42-056Jrg mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal B cell differentiation ( J:192126 )
• tamoxifen-treated mice exhibit an increase in B lymphoid cells in the bone marrow compared with control mice
abnormal T cell differentiation ( J:192126 )
• tamoxifen-treated mice exhibit an increase in T lymphoid cells in the bone marrow compared with control mice
increased hematopoietic stem cell number ( J:192126 )
• in tamoxifen-treated mice
abnormal hematopoietic stem cell physiology ( J:192126 )
• long-term hematopoietic stem cells from tamoxifen-treated mice exhibit increased oxygen consumption rates and lower levels of lactate indicating decreased cytoplasmic glycolysis compared with control cells
• long-term hematopoietic stem cells from tamoxifen-treated mice exhibit loss of quiescence compared with control cells

immune system
abnormal B cell differentiation ( J:192126 )
• tamoxifen-treated mice exhibit an increase in B lymphoid cells in the bone marrow compared with control mice
abnormal T cell differentiation ( J:192126 )
• tamoxifen-treated mice exhibit an increase in T lymphoid cells in the bone marrow compared with control mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory