Phenotypes Associated with This Genotype

Genotype
MGI:5464913

• Allelic Composition: Sox2^tm1.2Vlcg/Sox2^tm1.2Vlcg
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Sox2^tm1.2Vlcg/Sox2^tm1.2Vlcg and Sox2^tm1.1Vep/Sox2^tm1.2Vlcg embryos form disorganized extraembryonic tissues, but fail to form the epiblast, phenocopying Sox2^tm1.1Vep/Sox2^tm1.1Vep embryos

mortality/aging

embryonic lethality between implantation and placentation, complete penetrance ( J:191980 )

• shortly after implantation

embryo

absent embryonic epiblast ( J:191980 )

• lack the epithelial cells typical of epiblast

absent egg cylinders ( J:191980 )

increased trophoblast giant cell number ( J:191980 )