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Phenotypes Associated with This Genotype
Genotype
MGI:5464113
Allelic
Composition		 Vps52tm1.1Kab/Vps52tm1.2Kab
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background		 involves: C57BL * C57BL/6 * CBA * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (44 available)
Vps52tm1.1Kab mutation (1 available); any Vps52 mutation (41 available)
Vps52tm1.2Kab mutation (1 available); any Vps52 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

embryo
abnormal vitelline vasculature morphology ( J:190873 )
• vascular congestion is detected in the yolk sac at E8.5
disorganized yolk sac vascular plexus ( J:190873 )
• severe disruption of normal vascular patterning during yolk sac vasculogenesis
abnormal embryonic tissue morphology ( J:190873 )
• at E9.5 the rostral half of the embryo is formed almost normally but development of the caudal half is retarded

cardiovascular system
abnormal vitelline vasculature morphology ( J:190873 )
• vascular congestion is detected in the yolk sac at E8.5
disorganized yolk sac vascular plexus ( J:190873 )
• severe disruption of normal vascular patterning during yolk sac vasculogenesis

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory