Phenotypes for Tab2 Tg(Tek-cre)12Flv MGI:5464103 MGI Mouse

About Help FAQ

Phenotypes Associated with This Genotype

Allelic Composition	Tab2^tm2.1Aki/Tab2^tm2.1Aki Tg(Tek-cre)12Flv/0
Genetic Background	involves: 129P2/OlaHsd * C3H * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tab2^tm2.1Aki mutation (0 available); any Tab2 mutation (29 available)
Tg(Tek-cre)12Flv mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:191285 )

• mice die at E12.5

cardiovascular system

abnormal vascular development ( J:191285 )

• as in Map3k7^tm1Aki/Map3k7^tm1Aki Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak Tg(Tek-cre)12Flv mice

• however, endothelial cell proliferation and apoptosis rates are normal

abnormal vitelline vasculature morphology ( J:191285 )

• yolk sacs exhibit lagoon-like and less-branched vessel structures compared with control mice

embryo

abnormal vitelline vasculature morphology ( J:191285 )

• yolk sacs exhibit lagoon-like and less-branched vessel structures compared with control mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/18/2025 MGI 6.24