Phenotypes Associated with This Genotype

Genotype
MGI:5463978

• Allelic Composition: Gt(ROSA)26Sor^{tm7(Pik3ca*,-EGFP)Rsky}/Gt(ROSA)26Sor^{tm13(CAG-MYC,-CD2*)Rsky}; Ighg1^tm1(cre)Cgn/Ighg1⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:191824 )

• when bone marrow is used to reconstitute Rag2 and Il2rg null mice stimulated with sheep red blood cells, median survival is 227 days

immune system

abnormal class switch recombination ( J:191824 )

• impaired

increased germinal center B cell number ( J:191824 )

• in the Peyer's patches and spleen

neoplasm

increased B cell derived lymphoma incidence ( J:191824 )

• of germinal center B cell origin when bone marrow is used to reconstitute Rag2 and Il2rg null mice stimulated with sheep red blood cells

hematopoietic system

abnormal class switch recombination ( J:191824 )

• impaired

increased germinal center B cell number ( J:191824 )

• in the Peyer's patches and spleen