Phenotypes Associated with This Genotype

Genotype
MGI:5463972

• Allelic Composition: Atmin^tm1.2Jhh/Atmin^tm1.2Jhh; Cd79a^tm1(cre)Reth/Cd79a⁺
• Genetic Background: involves: BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Small spleen size in Atmin^tm1.2Jhh/Atmin^tm1.2Jhh/ Cd79a^tm1(cre)Reth/Cd79a⁺ mice

immune system

abnormal B cell differentiation ( J:191832 )

• impaired in a cell-intrinsic manner

• not rescued by provision of a prearranged BCR

decreased immature B cell number ( J:191832 )

• more than 7-fold in the bone marrow

decreased mature B cell number ( J:191832 )

• more than 7-fold in the spleen

decreased pre-B cell number ( J:191832 )

• 3-fold in the bone marrow

small spleen ( J:191832 )

• 2-fold

decreased spleen weight ( J:191832 )

abnormal B cell physiology ( J:191832 )

• immature and transitional B cells exhibit a 3-fold increase in cell death compared with control cells

hematopoietic system

abnormal B cell differentiation ( J:191832 )

• impaired in a cell-intrinsic manner

• not rescued by provision of a prearranged BCR

decreased immature B cell number ( J:191832 )

• more than 7-fold in the bone marrow

decreased mature B cell number ( J:191832 )

• more than 7-fold in the spleen

decreased pre-B cell number ( J:191832 )

• 3-fold in the bone marrow

small spleen ( J:191832 )

• 2-fold

decreased spleen weight ( J:191832 )

abnormal B cell physiology ( J:191832 )

• immature and transitional B cells exhibit a 3-fold increase in cell death compared with control cells