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Phenotypes Associated with This Genotype
Genotype
MGI:5462095
Allelic
Composition
Notch3tm1.1Dwr/Notch3tm1.1Dwr
Genetic
Background
involves: 129S/SvEv * Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch3tm1.1Dwr mutation (0 available); any Notch3 mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• somewhat (J:191454)
• somewhat (J:191454)
• in 9 of 73 mice develop overt permanent motor disability, ataxia or both (J:191454)
• in 9 of 73 mice develop overt permanent motor disability, ataxia or both (J:191454)
• in 9 of 73 mice, 3 of which show staggering ataxic gait (J:191454)
• in 9 of 73 mice, 3 of which show staggering ataxic gait (J:191454)
• of one or more limb in 8 of 9 mice with motor disabilities (J:191454)
• of one or more limb in 8 of 9 mice with motor disabilities (J:191454)

cardiovascular system
N
• mice exhibit normal vascular smooth muscle cell remodeling or growth and normal cerebral capillary densities (J:191454)
• mice exhibit normal vascular smooth muscle cell remodeling or growth and normal cerebral capillary densities (J:191454)
• mice exhibit arteriopathy with granular osminophilic material deposits in the basal lamina of the arterial smooth muscle cells and surrounding matrix in brain and tail arteries (J:191454)
• mice exhibit arteriopathy with granular osminophilic material deposits in the basal lamina of the arterial smooth muscle cells and surrounding matrix in brain and tail arteries (J:191454)

nervous system
• micro-bleeds, hemosiderin deposits or hemosiderin-containing macrophages, perivascular inflammatory infiltration, gliosis, thrombosis, perivascular fibrin(ogen) deposition, microinfarctions characterized by foci with pallor and cell loss around small cystic cavities, and enlargement of the Virchow-Robin spaces creating perivascular lacunae (J:191454)
• micro-bleeds, hemosiderin deposits or hemosiderin-containing macrophages, perivascular inflammatory infiltration, gliosis, thrombosis, perivascular fibrin(ogen) deposition, microinfarctions characterized by foci with pallor and cell loss around small cystic cavities, and enlargement of the Virchow-Robin spaces creating perivascular lacunae (J:191454)
• in some mice (J:191454)
• in some mice (J:191454)

homeostasis/metabolism
• in the brain vasculature of some mice (J:191454)
• in the brain vasculature of some mice (J:191454)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory