Phenotypes Associated with This Genotype

Genotype
MGI:5461494

• Allelic Composition: Gadd45g^tm1Jni/Gadd45g^tm1Jni
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal ovary morphology ( J:191096 )

• histologically some XY ovaries appear similar to XX ovaries while others are hypoplastic with very few or no follicles

abnormal ovarian follicle number ( J:191096 )

• some XY ovaries are hypoplastic with very few or no follicles

small ovary ( J:191096 )

• ovaries in XY females appear smaller than in XX wild-type females when examined microscopically

ovary cyst ( J:191096 )

• commonly detected in XY ovaries

abnormal testis development ( J:191096 )

• expression analysis indicates disruption of expression of testis determining genes

primary sex reversal ( J:191096 )

• reproductive tracts of XY mice have a predominantly female phenotype with identifiable ovaries and oviduct and uterine structures

• histologically some XY ovaries appear similar to XX ovaries while others are hypoplastic with very few or no follicles

secondary sex reversal ( J:191096 )

• reproductive tracts of XY mice have a predominantly female phenotype with identifiable ovaries and oviduct and uterine structures

infertility ( J:191096 )

• sex reversed XY females are infertile; but exhibit normal mating behavior

• XX female mice are fertile

endocrine/exocrine glands

abnormal ovary morphology ( J:191096 )

• histologically some XY ovaries appear similar to XX ovaries while others are hypoplastic with very few or no follicles

abnormal ovarian follicle number ( J:191096 )

• some XY ovaries are hypoplastic with very few or no follicles

small ovary ( J:191096 )

• ovaries in XY females appear smaller than in XX wild-type females when examined microscopically

ovary cyst ( J:191096 )

• commonly detected in XY ovaries

abnormal testis development ( J:191096 )

• expression analysis indicates disruption of expression of testis determining genes

growth/size/body

ovary cyst ( J:191096 )

• commonly detected in XY ovaries