Phenotypes Associated with This Genotype

Genotype
MGI:5461330

• Allelic Composition: Bcl6^tm1.1Mtto/Bcl6^tm1.1Mtto; Tg(Cd4-cre)1Cwi/0
• Genetic Background: involves: C57BL/6 * C57BL/6JJcl * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal somatic hypermutation frequency ( J:190943 )

• in memory B cells from mice immunized with NP-CG

decreased germinal center B cell number ( J:190943 )

• in mice immunized with NP-CG at day 40 but not day 7

absent germinal center B cells ( J:190943 )

• NP-CG immunized mice fail to generate NP-specific germinal center B cells at day 40

decreased T follicular helper cell number ( J:190943 )

• in mice immunized with NP-CG fail to develop T follicular helper cells at day 7 and 40

abnormal humoral immune response ( J:190943 )

• memory B cells from mice treated with NP-CG produce low affinity antibodies in an IgG1 secondary response unlike wild-type cells

hematopoietic system

abnormal somatic hypermutation frequency ( J:190943 )

• in memory B cells from mice immunized with NP-CG

decreased germinal center B cell number ( J:190943 )

• in mice immunized with NP-CG at day 40 but not day 7

absent germinal center B cells ( J:190943 )

• NP-CG immunized mice fail to generate NP-specific germinal center B cells at day 40

decreased T follicular helper cell number ( J:190943 )

• in mice immunized with NP-CG fail to develop T follicular helper cells at day 7 and 40