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Phenotypes Associated with This Genotype
Genotype
MGI:5461308
Allelic
Composition
Men1tm1Rvt/Men1+
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Men1tm1Rvt mutation (0 available); any Men1 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system

mortality/aging
• associated with tumor development

reproductive system
• in mice older than 12 months

neoplasm
• due to loss of allelic heterozygosity
• in 5% of mice younger than 9 months
• in 84% of mice older than 12 months (parathyroid, pancreatic islet, anterior pituitary, adrenal cortex, thyroid, testis and ovary)
• in mice older than 12 months
• in mice older than 12 months
• in mice older than 12 months
• in mice older than 12 months
• solid or papillary adenomas
• in mice older than 12 months

homeostasis/metabolism
N
• mice exhibit normal parathyroid hormone and chromogranin A serum levels
• in one male mouse with adrenal cortical tumors
• in mice with parathyroid proliferative abnormalities
• in mice with thyroid abnormalities
• in mice with parathyroid proliferative abnormalities
• however, mice with thyroid abnormalities exhibit normal phosphate serum levels

endocrine/exocrine glands
• in mice older than 12 months
• in mice older than 12 months
• in mice older than 12 months
• in mice older than 12 months
• solid or papillary adenomas
• in mice older than 12 months

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
multiple endocrine neoplasia type 1 DOID:10017 OMIM:131100
J:191261


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory