Phenotypes for Calca Rb1 Trp53 MGI:5460840 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Calca^{tm1.1(cre/ERT2)Ptch}/Calca⁺ Trp53^tm1Brn/Trp53^tm1Brn Rb1^tm2Brn/Rb1^tm2Brn
Genetic Background	involves: 129 * 129P2/OlaHsd * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Calca^{tm1.1(cre/ERT2)Ptch} mutation (0 available); any Calca mutation (23 available)
Rb1^tm2Brn mutation (3 available); any Rb1 mutation (117 available)
Trp53^tm1Brn mutation (21 available); any Trp53 mutation (249 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality ( J:190366 )

• death within 6-7 months of tamoxifen treatment

respiratory system

increased lung small cell carcinoma incidence ( J:190366 )

• small cell lung tumors 5-6 months after tamoxifen treatment in 4 of 32 mice examined, all with pulmonary neuroendocrine cells hyperplasia as well

abnormal pulmonary neuroendocrine body morphology ( J:190366 )

• pulmonary neuroendocrine cells hyperplasia 5-6 months after tamoxifen treatment in 16 of 32 mice examined

• increased proliferation of pulmonary neuroendocrine cells

neoplasm

increased thyroid tumor incidence ( J:190366 )

• all mice develop thyroid tumors

increased lung small cell carcinoma incidence ( J:190366 )

• small cell lung tumors 5-6 months after tamoxifen treatment in 4 of 32 mice examined, all with pulmonary neuroendocrine cells hyperplasia as well

endocrine/exocrine glands

increased thyroid tumor incidence ( J:190366 )

• all mice develop thyroid tumors

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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