Phenotypes Associated with This Genotype

Genotype
MGI:5450878

• Allelic Composition: Rest^tm1Ymat/Rest^tm1Ymat
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:190948 )

• die by E11.5

reproductive system

decreased primordial germ cell number ( J:190948 )

• at E9.5 the number of migrating PGCs is reduced compared to heterozygous controls

• the increase in number of PGCs during development is reduced

increased primordial germ cell apoptosis ( J:190948 )

• increase in the ratio of apoptotic to viable PGCs at E9.25

• however, proliferation of PGCs is similar to controls

nervous system

abnormal cranial flexure morphology ( J:190948 )

• wider

abnormal forebrain morphology ( J:190948 )

cellular

decreased primordial germ cell number ( J:190948 )

• at E9.5 the number of migrating PGCs is reduced compared to heterozygous controls

• the increase in number of PGCs during development is reduced

increased primordial germ cell apoptosis ( J:190948 )

• increase in the ratio of apoptotic to viable PGCs at E9.25

• however, proliferation of PGCs is similar to controls