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Phenotypes Associated with This Genotype
Genotype
MGI:5450878
Allelic
Composition
Resttm1Ymat/Resttm1Ymat
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Resttm1Ymat mutation (0 available); any Rest mutation (52 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

reproductive system
• at E9.5 the number of migrating PGCs is reduced compared to heterozygous controls
• the increase in number of PGCs during development is reduced
• increase in the ratio of apoptotic to viable PGCs at E9.25
• however, proliferation of PGCs is similar to controls

nervous system

cellular
• at E9.5 the number of migrating PGCs is reduced compared to heterozygous controls
• the increase in number of PGCs during development is reduced
• increase in the ratio of apoptotic to viable PGCs at E9.25
• however, proliferation of PGCs is similar to controls


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory