Rest^tm1Ymat
Targeted Allele Detail

Summary

• Symbol: Rest^tm1Ymat
• Name: RE1-silencing transcription factor; targeted mutation 1, Yasuhisa Matsui
• MGI ID: MGI:5450873
• Gene: Rest Location: Chr5:77413338-77434279 bp, + strand Genetic Position: Chr5, 41.61 cM
• Alliance: Rest^tm1Ymat page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:190948
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exon 1 was replaced with a pgk-neo cassette in the inverse orientation via homologous recombination. (J:190948)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rest Mutation: 95 strains or lines available

References

• Original: J:190948 Okamura D, et al., REST and its downstream molecule Mek5 regulate survival of primordial germ cells. Dev Biol. 2012 Dec 15;372(2):190-202
• All: 1 reference(s)