Phenotypes Associated with This Genotype

Genotype
MGI:5448156

• Allelic Composition: Foxo1^tm1Flv/Foxo1^tm1Flv; Ifng^tm1Ts/Ifng^tm1Ts; Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺
• Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129S7/SvEvBrd * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:189962 )

N • the lethal inflammatory phenotype is partially rescued

immune system

immune system phenotype ( J:189962 )

N • regulatory T cells are able to suppress development of colitis in Rag1 null mice receiving naive T cells

increased CD4-positive, alpha-beta T cell number ( J:189962 )

• elevated numbers in the spleen and peripheral lymph nodes are partially rescued compared to in Foxo1^tm1Flv/Foxo1^tm1Flv Foxp3^{tm4(YFP/cre)Ayr}/Foxp3⁺ mice

increased CD8-positive, alpha-beta T cell number ( J:189962 )

• elevated numbers in the spleen and peripheral lymph nodes are partially rescued compared to in Foxo1^tm1Flv/Foxo1^tm1Flv Foxp3^{tm4(YFP/cre)Ayr}/Foxp3⁺ mice

hematopoietic system

increased CD4-positive, alpha-beta T cell number ( J:189962 )

• elevated numbers in the spleen and peripheral lymph nodes are partially rescued compared to in Foxo1^tm1Flv/Foxo1^tm1Flv Foxp3^{tm4(YFP/cre)Ayr}/Foxp3⁺ mice

increased CD8-positive, alpha-beta T cell number ( J:189962 )

• elevated numbers in the spleen and peripheral lymph nodes are partially rescued compared to in Foxo1^tm1Flv/Foxo1^tm1Flv Foxp3^{tm4(YFP/cre)Ayr}/Foxp3⁺ mice