Mouse Genome Informatics
cn
    Jag1tm1Frad/Jag1tm1Frad
Tg(Cdh5-cre)7Mlia/0

B6.Cg-Jag1tm1Frad Tg(Cdh5-cre)7Mlia
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
N
• contrary to previous reports, viable mice are produced (J:166890)

cardiovascular system
• abnormal positioning of the aorta and pulmonary trunk
• abnormal positioning of the aorta and pulmonary trunk
• fragile and hemorrhaging in embryos and neonates
• thin and disorganized
• incomplete at E14.5
• large and hyperplastic (myxomatous)
• neonates exhibit bulges near the valve annulus
• cartilage nodules and calcification in the annulus of adults
• thick at P10 with lower nuclear density indicating changes in the extracellular matrix rather than increase in cell density
• increased outflow tract valve leaflet width in adults
• in right ventricle
• near the apex
• with severe regurgitation at the pulmonic valve

liver/biliary system
N
• mice exhibit normal bile duct formation (J:166890)

Mouse Models of Human Disease
OMIM IDRef(s)
Alagille Syndrome 1; ALGS1 118450 J:189213