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Phenotypes Associated with This Genotype
Genotype
MGI:5447165
Allelic
Composition
Jag1tm1Frad/Jag1tm1Frad
Tg(Tagln-cre)1Her/0
Genetic
Background
B6.Cg-Jag1tm1Frad Tg(Tagln-cre)1Her
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jag1tm1Frad mutation (0 available); any Jag1 mutation (35 available)
Tg(Tagln-cre)1Her mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most mice die within 2 days of birth with few surviving beyond 4 weeks
• most mice die within 2 days of birth with few surviving beyond 4 weeks

liver/biliary system
• multifoci
• absent or incompletely formed bile ducts near the portal veins
• biliary epithelial cells are unable to organize into tubules; portal vein mesenchyme is reduced
• epithelial cells fail to aggregate
• accumulation of bile in liver parenchyma
• at birth

homeostasis/metabolism
• total and conjugated
• increased circulating gamma-glutamyl transferase

growth/size/body
• at birth and in mice that survive beyond 4 weeks, worsening over time

behavior/neurological
• in mice that survive beyond 4 weeks, worsening over time

cardiovascular system
• multifoci

integument
• in mice that survive beyond 4 weeks, worsening over time

endocrine/exocrine glands
• absent or incompletely formed bile ducts near the portal veins
• biliary epithelial cells are unable to organize into tubules; portal vein mesenchyme is reduced
• epithelial cells fail to aggregate

Mouse Models of Human Disease
OMIM ID Ref(s)
Alagille Syndrome 1; ALGS1 118450 J:166890


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory